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P.O. Box 9101
6500 HB, Nijmegen
The Netherlands
Geert Grooteplein 28
6525 GA, Nijmegen
The Netherlands
T +31 24 3610556
F +31 24 3540339

Alessandra Cambi is currently staff member at the Tumor Immunology Department. She holds a PhD in Biology (University of Camerino, Italy) and a PhD in Medical Sciences (Radboud University, Nijmegen, The Netherlands). In 2005 and 2006 she was an EMBO postdoctoral fellow at the Max Planck Institute in Göttingen, Germany. In 2006, she obtained a Veni fellowship from the Netherlands Organization for Scientific research (NWO), followed in 2008 by a Young Investigator Grant from the Human Frontier Science Program.
Since November 2009 she is the recipient of a NWO Meervoud subsidy. Her research focuses on the role of plasma membrane compartmentalization in the regulation of immune receptor signalling and the application of high-resolution microscopy.
Dr. Alessandra Cambi

Research interests include immunology and cell biology, with a specific focus on the application of high resolution microscopy to unravel the organization and dynamics of receptors and lipids at the plasma membrane. Major current projects include the investigation of the role of plasma membrane lipids in the regulation of pathogen receptor functions on dendritic cells as well as the function of prostaglandin receptors involved in the communication between dendritic cells and mast cells.
 
Recent key publications


van Zanten TS*, Cambi A*, Koopman M, Joosten B, Figdor CG, Garcia-Parajo MF. Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18557-62. (*equally contributing authors).

Cambi A, Beeren I, Joosten B, Fransen JA and Figdor CG (2009) The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virions via a clathrin-dependent mechanism. Eur.J. Immunol. DOI: 10.1002/eji.200939351

Cambi A and Figdor CG (2009) Necrosis: C-type lectins sense cell death. Curr. Biol 19(9):R375-8.

Diez-Ahedo R, Normanno D, Esteban O, Bakker G, Figdor CG, Cambi A and Garcia-Parajò MF (2009) Dynamic re-organization of individual adhesion nanoclusters in living cells by ligand patterned surfaces. SMALL 5(11):1258-1263

Cambi A, Netea MG, Mora-Montes HM, Gow NA, Hato SV, Lowman DW, Kullberg B-J, Torensma R, Williams DL, and Figdor CG. (2008). Dendritic cell interaction with Candida albicans critically depends on N-linked mannan. J. Biol. Chem. 283:20590-20599.