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Prof. Dr. Carl Figdor Research interests include immunology and cell biology, with a specific focus on the molecular mechanisms controlling antigen presenting cells, in particular dendritic cells. Major current projects include an investigation of the role of lectin-like receptors in antigen uptake and the role of the cytoskeleton in dendritic cell adhesion and migration. The use of high resolution single cell imaging tools to achieve greater insights into the topography of cell surface receptors and the advancement of translational medicine through the treatment of cancer patients using antigen loaded dentritic cell vaccines are among his current fascinations as an immunologist. |
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Recent key publications D., Tacken, P., Punt, C.J., de Vries, I.J., Figdor, C.G. Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II. Benitez-Ribas., J Immunol, 2008. 181(8): 5219-24 Tacken, P.J., Joosten, B., Reddy, A., Wu, D., Eek, A., Laverman, P., Kretz-Rommel, A., Adema, G.J., Torensma, R., Figdor, C.G. No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation. J Immunol, 2008. 180(11): 7687-96. van Helden, S.F., Oud, M.M., Joosten, B., Peterse, N., Figdor, C.G., van Leeuwen, F.N. PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis. J Cell Sci, 2008. 121(Pt 7): 1096-106 |
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