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Prof. dr. Gosse Adema
Research interests focus on the molecular analysis of professional antigen presenting
dendritic cells and T-regulatory cells, and their function in the immune system
in health and disease. Major current projects include i) functional analysis
of DC-STAMP, lectins and toll-like receptors in dendritic cell biology and ii)
pre-clinical mouse studies on the role of dendritic cells and T-regulatory cells
in immunotherapy of cancer. The knowledge gathered in the fundamental immunological
studies is translated into clinical vaccination studies of cancer patients with
autologous, antigen-loaded dendritic cell vaccines.
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Recent key publications den Brok MH, Sutmuller RP, van der Voort R, Bennink EJ, Figdor CG, Ruers TJ, Adema GJ. In situ tumor ablation creates an antigen source for the generation of antitumor immunity. Cancer Res. 2004;64(11):4024-9. Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. J Leukoc Biol. 2004 Dec 15. Schaft N, Willemsen RA, de Vries J, Lankiewicz B, Essers BW, Gratama JW, Figdor CG, Bolhuis RL, Debets R, Adema GJ. Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes. J Immunol. 2003;170(4):2186-94. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol. 2002; 2(2):77-84. Review. |
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