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Nephrology 545
Radboud University Nijmegen Medical Centre
P.O. Box 9101
6500 HB, Nijmegen
The Netherlands
T +31 24 3614761
F +31 24 3540022

Luuk Hilbrands (1962) is internist-nephrologist and staff member of the Department of Nephrology. He is especially involved in the care of renal transplant patients.
Dr. L.B. Hilbrands

Areas of research contain clinical as well as experimental topics. Clinical trials are designed to evaluate new treatments for improving patient outcome after renal transplantation. In addition, novel approaches for immunological monitoring after transplantation are explored. Experimental research is directed towards the induction of donor-specific tolerance after transplantation. To achieve this goal, the role of immature dendritic cells as well as the induction of regulatory T cells are investigated. The ultimate aim is the translation of new knowledge obtained in these projects into clinical application.

 
Recent key publications

Peters JH, Preijers FW, Woestenenk R, Hilbrands LB, Koenen HJ, Joosten I. Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation. PLoS ONE. 2008 Sep 8;3(9):e3161.

Kreijveld E, Koenen HJ, van Cranenbroek B, van Rijssen E, Joosten I, Hilbrands LB. Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus. PLoS ONE. 2008 Jul 16;3(7):e2711.

Peters JH, Hilbrands LB, Koenen HJ, Joosten I. Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy. PLoS ONE. 2008 May 21;3(5):e2233.