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Dr. Peter M. van der Kraan
Research interests include the pathophysiology of osteoarthritis and cartilage biology with a special interest in the role of growth factors (e.g. TGF beta, BMPs, CTGF) in pathological processes. Research is focused on the elucidation of the mechanism of cartilage destruction in osteoarthritis and application of this knowledge in the prevention of cartilage damage and the stimulation of cartilage repair. Research covers the continuum of cartilage destruction to cartilage repair and cartilage tissue engineering. |
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Recent key publications
van der Kraan PM, van den Berg WB. Osteoarthritis in the context of ageing and evolution Loss of chondrocyte differentiation block during ageing. Ageing Res Rev. 2008 Apr;7(2):106-13.
Blaney Davidson EN, Vitters EL, van Beuningen HM, van de Loo FA, van den Berg WB, van der Kraan PM. Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. Arthritis Rheum. 2007 Dec;56(12): 4065-73.
Blaney Davidson EN, van der Kraan PM, van den Berg WB. TGF-beta and osteoarthritis. Osteoarthritis Cartilage. 2007 Jun;15(6):597-604.
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van der Kraan PM, van den Berg WB. Osteophytes: Relevance and biology. Osteoarthritis Cartilage. 2007 Mar;15(3):237-44.
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Blaney Davidson EN, Vitters EL, Mooren FM, Oliver N, Berg WB, van der Kraan PM. Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage. Arthritis Rheum. 2006
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