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P.O. Box 9101
6500 HB, Nijmegen
The Netherlands
Geert Grooteplein 28
6525 GA, Nijmegen
The Netherlands
T +31 24 3614580
F +31 24 3541433

Timothy Radstake is junior Principal investigator at the department of Rheumatology. In addition, he fulfills the role of assistant professor at the Arthritis Center at the Boston University School of Medicine, Boston, USA.  

 
Dr. Timothy Radstake

Research interests include the role of the immune system in autoimmune and auto inflammatory rheumatic conditions. Special interests include the role of dendritic cells, Fc gamma receptors and Toll like receptors in rheumatoid arthritis, sero negative spondylarthropathies and systemic sclerosis.
 
Recent key publications

Radstake TR, van Bon L, Broen J, Hussiani A, Hesselstrand R, et al. (2009) The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 4: e5903.

Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, et al. (2009) Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One 4: e5981.

Roelofs MF, Wenink MH, Brentano F, Abdollahi-Roodsaz S, Oppers-Walgreen B, et al. (2008) Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4 mediated synovial inflammation in rheumatoid arthritis (RA). Ann Rheum Dis Ann Rheum Dis. 2008 Sep 2. [Epub ahead of print]

Rueda B, Broen J, Simeon C, Hesselstrand R, Diaz B, et al. (2009) The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet 2009 Jun 1;18(11):2071-7. Epub 2009 Mar 13.

van Lieshout AW, Vonk MC, Bredie SJH, Joosten I, Netea MG, et al. Enhanced IL-10 production by dendritic cells upon stimulation with TLR4 agonists in systemic sclerosis potentially drives increased levels of the pro-fibrotic chemokine CCL18. J Clin Rheumatol 2009 Mar 2:1-9. [Epub ahead of print]