Description of theme 1
Description of theme 2
Description of theme 3
   
 

Dept. Cell Biology
P.O. Box 9101
6500 HB Nijmegen

Geert Grooteplein 28
6525 GA, Nijmegen
The Netherlands
T: +31 24 3617600
F: +31 24 3540339

Bé Wieringa is full professor in Cell Biology (structural chair) and is the head of the Cell Biology Department. Formerly, he was chairman of the board of directors of the research school NCMLS. He was and is member of various scientific advisory and evaluation boards, within the Radboud University and (inter)national Science and Charity Fund organizations. He is also member of the Editorial Board of FEBS Letters and reviewer for journals in the molecular life sciences area.
Prof. Dr. Bé Wieringa

Research interests are in the area of molecular cell biology and molecular genetics and include the (patho)biological significance of (i) compartmentalized cellular energy and redox reactions, i.e. local reactions involving allosteric binding or metabolic conversion of ATP and NAD(P)(H)), and (ii) actin-based cell shape dynamics involved in phagocytosis, bone and brain remodeling in development, and (tumor) cell migration. Attention in current projects is focused on the use of molecular and microscopy approaches for visualization of the role of cellular ATP-NAD(P)(H) metabolism in viability and growth control in early transformed tumor cells and on (ii) the reciprocal coupling between energy-redox metabolism and mode of actin-driven (tumor) cell migration or phagocytosis by macrophages. Likewise, the role of the ATP-to- actin axis in functional dynamics of astrocytes, osteoclasts and myoblasts-myotubes is being analyzed. A complete other line of Bé’s research involves (iii) use of cell and animal models to study the genetic and molecular causes of Myotonic Dystrophy Type 1 (DM1), with the ultimate aim to develop help and therapy for the multisystemic problems that are associated with this frequent inheritable neuromuscular disorder.
 

Recent key publications

Mulders SA, van den Broek WJ, Wheeler TM, Croes HJ, van Kuik-Romeijn P, de Kimpe SJ, Furling D, Platenburg GJ, Gourdon G, Thornton CA, Wieringa B, Wansink DG (2009) Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy. Proc Natl Acad Sci U S A.  106(33):13915-20. Epub 2009 Aug 10.

de Groof AJ, te Lindert MM, van Dommelen MM, Wu M, Willemse M, Smift AL, Winer M, Oerlemans F, Pluk H, Fransen JA, Wieringa B (2009) Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype. Mol Cancer. 8:54.

van Horssen R, Janssen E, Peters W, van de Pasch L, Lindert MM, van Dommelen MM, Linssen PC, Hagen TL, Fransen JA, Wieringa B (2009).Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity. J Biol Chem. 284(3):1620-7. Epub 2008 Nov 12.

Chang EJ, Ha J, Oerlemans F, Lee YJ, Lee SW, Ryu J, Kim HJ, Lee Y, Kim HM, Choi JY, Kim JY, Shin CS, Pak YK, Tanaka S, Wieringa B, Lee ZH, Kim HH.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone
resorption. Nat Med. 2008 Sep;14(9):966-72. PubMed PMID: 18724377.

Kuiper, J.W.P., Pluk, H., Oerlemans, F, Leeuwen, F.N. van, Lange, F. de, Fransen, J. & Wieringa, B. (2008). Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis. Plos Biology, 6(3), e51.