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Prof. Dr. René J.M. Bindels
Research interests focus on the regulation of ion transport processes in kidney and small intestine. Current projects involve the molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular. In addition, the functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia are investigated. The studies include use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity. |
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Recent key publications van de Graaf SF, Chang Q, Mensenkamp AR, Hoenderop JG, Bindels RJ. Direct interaction with Rab11 targets the epithelial Ca2+ channels TRPV5 and TRV6 to the plasma membrane. Mol Cel Biol 26: 303-312, 2006.
Lambers T, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp A, Voets T, Nilius B, Clapham D, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. Embo J 25: 2978-2988, 2006 Nijenhuis T, van de Kemp A, Loffing J, Hoenderop JG, Bindels RJ. Enhanced passive calcium reabsorption and reduced magnesium channel abundance explaining thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 115: 1651-1658, 2005 Chang Q, Hoefs S, van der Kemp A, Topala A, Bindels RJ, Hoenderop JG. TRPV5 channel activation on the cell surface depends on extracellular glycan hydrolysis by the ß-glucuronidase klotho. Science 310: 490-493, 2005 Hoenderop JG, Nilius B, Bindels RJ. Calcium absorption in epithelia. Phys Reviews 85: 373-422, 2005 More publications |
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