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P.O. Box 9101
6500 HB, Nijmegen
Geert Grooteplein 28
6525 GA, Nijmegen
The Netherlands
T +31 24 3617600
F +31 24 3540339

Ad Geurts van Kessel is head of the Cytogenetics division of the department of Human Genetics since 1989. He was appointed professor of Tumour Cell Genetics in 1993 and in the same year he became deputy head of the department of Human Genetics. He is responsible for the establishment of the central NCMLS Microarray facility.
Prof. Dr. Ad Geurts van Kessel

Research interests include chromosome aberrations and cancer, with special emphasis on transcription (de)regulation, cell cycle checkpoint (de)regulation, familial and childhood cancer syndromes. He also has interests in translational research and technology development. Major current projects focus on renal cell carcinomas, synovial sarcomas, pediatric leukemias and familial cancer syndromes including colorectal cancer. The implementation of (ultra) high resolution microarray-based genome profiling and next generation sequencing technologies in basic research and clinical application is also a primary interest.
 
Recent key publications

R.P. Kuiper, M.L.M. Ligtenberg, N. Hoogerbrugge, A. Geurts van Kessel. Germline copy number variation and cancer risk. Curr. Opin. Genet. Dev. 20: 282-289 (2010).

M.J. Ligtenberg, R.P Kuiper, T.L. Chan, M. Goossenes, K.M. Hebeda, M. Voorendt, T.Y.H. Lee, D. Bodmer, E. Hoenselaar, H.G. Brunner, A. Geurts van Kessel, S.T. Yuen, J.H.J.M. van Krieken, S.Y. Leung and N. Hoogerbrugge. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3’ exons of TACSTD1. Nature Genet. 41: 112-117 (2009).

S. Langemeijer, R.P. Kuiper, M. Berends, R. Knops, M.G. Aslanyan, M. Massop, E. Stevens-Linders, P. van Hoogen, A. Geurts van Kessel, R.A.P. Raymakers, E..J. Kamping, G.E. Verhoef, E. Verburgh, A. Hagemeijer, P. Vandenberghe, T. de Witte, B.A. van der Reijden and J.H. Jansen. Acquired mutations in TET2 are common in myelodysplatic syndromes. Nature Genet. 41: 838-842 (2009).

D. Koolen, L. Vissers, R. Pfundt, N. de Leeuw, S. Knight, R. Regan, F. Kooy, E. Reyniers, C. Romano, M. Fichera, A. Schinzel, A. Baumer, B. Anderlid, J. Schoumans, N. Knoers, A. Geurts van Kessel, E. Sistermans, J. Veltman, H. Brunner and B. de Vries. A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism. Nature Genet. 38: 999-1001 (2006).

L.E.L.M. Vissers, C.M.A. van Ravenswaaij, R. Admiraal, J.A. Hurst, B.B.A. de Vries, I.M. Janssen, W.A. ven der Vliet, E.H.L.P.G. Huys, P.J. de Jong, B.C.J. Hamel, E.F.P.M. Schoenmakers, H.G. Brunner, J.A. Veltman and A. Geurts van Kessel. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nature Genet. 36: 955-957 (2004).