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Nephrology
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
T: +31 24 3614761
F: +31 24 3540022

Jo Berden received post-doctoral research training in immunology and immunopathology in 1981-1982 at the Scripps Reseach Foundation, La Jolla, California, US. He was appointed Professor of Nephrology in 1989, concentrating on immunology of renal diseases. He is head of the Division of Nephrology since May 2001 and was appointed as Full Professor of Nephrology in 2002.
Prof.dr. Jo H.M. Berden

Research interests are focused on clinical and fundamental aspects of both autoimmunity (especially lupus erythematosus) and glomerular diseases. Current research projects on lupus include epitope analysis of anti-nucleosome auto-antibodies, the impact of apoptosis induced modification on dendritic cells maturation and presentation and autoantibody formation and multi-centre randomised controlled trials on treatment of lupus nephritis. Research projects on glomerular diseases are aimed at the unraveling of prognostic determinants for diabetic nephropathy and at the role of heparan sulfate and dystroglycan in glomerular pathology. His fundamental research aims are initiated and fueled by observations and problems encountered in the clinical care of renal patients.

 

Recent key publications

Rops A, van den Hoven MJW, Baselmans M, Lensen JF, Wijnhoven TJ, van den Heuvel LPWJ, van Kuppevelt TH, Berden JHM, van der Vlag J. Heparan sulfate domains on cultured activated  glomerular endothelial cells mediate  leukocyte trafficking. Kidney Int  2008;  73: 52-62.

van den Hoven MJW, Wijnhoven TJ, Li JP, Zcharia E, Dijkman HB, Wismans RGP, Rops A, Lensen JF, van den Heuvel LPWJ, Vlodavsky I, Berden JH, van der Vlag J. Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria. Kidney Int  2008; 73: 278-87.

van Bavel C, Fenton KA, Rekvig OP, van der Vlag J, Berden JHM. Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus.   Arthritis Rheum  2008; 58: 1892-9.