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Jos W.M. van der Meer is Professor of Internal Medicine and Chairman of the Division of General Internal Medicine at Radboud University Nijmegen Medical Centre . He is a honorary fellow of the Royal College of Physicians, Knight in the order of the Dutch lion and a member of the Royal Netherlands Academy of Arts and Sciences.From May 2005onward he serves as the chairman of the Department of Natural Sciences of the Academy.
Professor Dr. Jos W.M. van der Meer

Research interests include infection and host defense, especially natural immunity as mediated by Toll like receptors and other pattern recognition receptors and by cytokines. The response in well defined infections such as disseminated fungal infections, meningococcal infections, tuberculosis are the focus of this research. Some of these studies (especially tuberculosis) are being performed in Indonesia and Tanzania within the Centre for Poverty-Related Infection Oriented Research (PRIOR). In addition, the auto inflammatory syndromes are an important area of research.

 
Recent key publications

Kullberg BJ, Sobel JD, Ruhnke M, Pappas PG, Viscoli C, Rex JH, Cleary JD, Rubinstein E, Church LW, Brown JM, Schlamm HT, Oborska IT, Hilton F, Hodges MR. Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial. Lancet 2005;366:1435-42.

Netea MG, Ferwerda G, de Jong DJ, Werts C, Boneca IG, Jehanno M, Van Der Meer JW, Mengin-Lecreulx D, Sansonetti PJ, Philpott DJ, Dharancy S, Girardin SE. The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem 2005;280:35859-67.

Netea MG, Ferwerda G, de Jong DJ, Jansen T, Jacobs L, Kramer M, Naber TH, Drenth JP, Girardin SE, Kullberg BJ, Adema GJ, Van der Meer JW. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol 2005;174:6518-23.

Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, Abraham E, Kim JM, Yoon DY, Dinarello CA, Kim SH. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A 2005;102:16309-14.

Ferwerda G, Girardin SE, Kullberg BJ, Le Bourhis L, de Jong DJ, Langenberg DM, van Crevel R, Adema GJ, Ottenhoff TH, Van der Meer JW, Netea MG. NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis. PLoS Pathog 2005;1:e34.