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PO Box 9101
6500 HB Nijmegen
Rene Descartesdreef 1
6525 GL, Nijmegen
The Netherlands
T: +31 24 3617245
F: +31 24 3541184

Patrick Zeeuwen is a senior research scientist at the Department of Dermatology. In 2004 he became a VENI laureate on the topic of epidermal proteases and their role in skin barrier formation and homeostasis. He recently received a Horizon grant from the Netherlands Genomics Initiative (ZonMw).
Dr. Patrick L.J.M. Zeeuwen

My research line focuses on cellular differentiation programs that regulate the formation and homeostasis of the epidermis. Experimental approaches include genetics, mouse models, and in vitro model systems for skin barrier function/dysfunction. We aim to get fundamental insights into the biology of skin barrier formation and cutaneous host defense mechanisms. From a clinical perspective, this work is relevant for elucidation of monogenic diseases and the proposed role of compromised skin barrier function in development of inflammatory skin diseases like psoriasis and atopic dermatitis.
 
Recent key publications

Hollox,E.J., Huffmeier,U., Zeeuwen,P.L., Palla,R., Lascorz,J., Rodijk-Olthuis,D., van de Kerkhof,P.C., Traupe,H., de Jongh,G.J., den Heijer,M., Reis,A., Armour,J.A., and Schalkwijk,J. Psoriasis is associated with increased beta-defensin genomic copy number. Nat. Genet., 2008. 40:23-25

Zeeuwen,P.L., de Jongh,G.J., Rodijk-Olthuis,D., Kamsteeg,M., Verhoosel,R.M., van Rossum,M.M., Hiemstra,P.S., and Schalkwijk,J. Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis. PLoS ONE, 2008. 3(6): e2301

Cheng,T., van Vlijmen-Willems,I.M., Hitomi,K., Pash,M.C., van Erp,P.E., Schalkwijk,J., and Zeeuwen,P.L. Colocalization of cystatin M/E and its target proteases suggests a role in terminal differentiation of the human hair follicle and nail. J. Invest. Dermatol. 2009. 129:1232-42

de Cid,R.*, Riveira-Munoz,E*, Zeeuwen,P.L.*, Robarge,J.*, Liao,W., Dannhauser,E.N., Giardina,E., Stuart,P.E., Nair,R., Helms,S., Escaramis,G., Ballana,E., Martin-Ezquerra,G., den Heijer,M., Kamsteeg,M., Joosten,I., Eichler,E.E., Lazara,C., Pujol,R.M., Armengol,L., Abecasis,G., Elder,J.T., Novelli,G., Armour,J.A., Kwok,P., Bowcock,A., Schalkwijk,J., and Estivill,X. Deletion of the late cornified envelope (LCE) 3C and 3B genes as a susceptibility factor for psoriasis. (*shared first authorship) Nat. Genet., 2009. 41:211-5

Zeeuwen,P.L., Cheng,T., and Schalkwijk,J. The biological role of cystatin M/E and its cognate target proteases. J. Invest. Dermatol. 2009. 129(6):1327-38