Hendriks

Wiljan Hendriks has a background in biochemistry and molecular biology. His group has been working on the signalling role of several protein tyrosine phosphatases in health and disease. The group has extensive experience in a variety of molecular biological and molecular genetic techniques. Work in vitro has concentrated on the protein interactions mediated by the PTPs to allow their positioning in cellular signalling pathways. Mutant mouse models generated in the group uncovered roles for PTPRF, PTPRR and PTPN13 in neuronal development and function, including nerve repair, motor coordination and learning and memory.

Wiljan Hendriks is an associate professor at the Cell Biology department of the Radboud University Nijmegen Medical Centre. In addition to his research activities on protein tyrosine phosphatase signalling in health and disease, he is a lecturer in cellular and molecular biology for students in medicine, health sciences and molecular life sciences.

• Navis AC, van den Eijnden M, Schepens JT, Hooft van Huijsduijnen R, Wesseling P, Hendriks WJ. Protein tyrosine phosphatases in glioma biology. Acta Neuropathol. 119:157-75, 2010.

• Hoover AC, Strand GL, Nowicki PN, Anderson ME, Vermeer PD, Klingelhutz AJ, Bossler AD, Pottala JV, Hendriks WJ, Lee JH. Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene. 28:3960-70, 2009.

• Glondu-Lassis M, Dromard M, Chavey C, Puech C, Fajas L, Hendriks W, Freiss G. Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis. Int J Biochem Cell Biol. 41:2173-80, 2009. 

• Hendriks WJ, Dilaver G, Noordman YE, Kremer B, Fransen JA. PTPRR Protein Tyrosine Phosphatase Isoforms and Locomotion of Vesicles and Mice. Cerebellum. 8:80-8, 2009.

• Uetani N, Bertozzi K, Chagnon MJ, Hendriks W, Tremblay ML, Bouchard M. Maturation of ureter-bladder connection by LAR receptor protein-tyrosine phosphatases. J Clin Invest. 119:924-35, 2009.