Hoenderop

Research interests include the regulation of Ca²⁺ and Mg²⁺ transport in epithelia with a specific focus on the molecular regulation of epithelial Ca²⁺ and Mg²⁺ channels (TRPV5&6 and TRPM6&7), members of the transient receptor potential (TRP) channels. Recent studies indicate that these channels function as gatekeepers to maintain the extracellular Ca²⁺ and Mg²⁺ balance which is crucial for mammalian development and function. His current work focuses on the functional aspects of these channels using a comprehensive approach that includes studies on epithelial cell lines and animal knockout models, identification of regulatory partners and electrophysiological analysis of channel activity.

Joost Hoenderop is full professor of Molecular Kidney Physiology, has a background in molecular biology and obtained his Ph.D. degree in Medical Sciences at the Radboud University Nijmegen in 2000. Subsequently, he held an EMBO fellowship at the Institute of Pharmacology and Toxicology at the University of Lausanne, Switzerland. He obtained the prestigious ZonMw Vernieuwingsimpuls grant, the Career Program from the Dutch Kidney Foundation and more recently the EURYI award from the European Science Foundation.

• Thébault S, Cao G, Venselaar H, Xi Q, Bindels RJ, Hoenderop JG. Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP. J Biol Chem. 283:19999-20007, 2008.

• Huybers S, Apostolaki M, van der Eerden BC, Kollias G, Naber TH, Bindels RJ, Hoenderop JG. Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters. Inflamm Bowel Dis. 14:803-11, 2008.

• Cao G, Thébault S, van der Wijst J, van der Kemp A, Lasonder E, Bindels RJ, Hoenderop JG. RACK1 a new auxiliary protein inhibiting TRPM6 activity via phosphorylation of the fused a-kinase domain. Curr Biol. 18:168-76, 2008.