Swinkels

Dorine Swinkels is a MD and chemist, specialized in clinical chemistry. Her  research aims at the full understanding of iron metabolism, in particular the identification and characterization of novel factors that affect dysregulation of iron homeostasis in various human disorders among which are some of the world's most prevalent diseases such as anemia of chronic kidney disease, hereditary hemochromatosis, inherited (iron loading) anemia's, bacterial and malarial infections. New findings are translated into novel diagnostic assays and therapeutic strategies that can be implemented in the clinic. Among her (team's) most recent achievements and activities are the development and harmonization of assays for the recently discovered iron regulatory hormone peptide hepcidin that is currently subject of several translational studies.

• Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW. Hepcidin in human iron disorders: diagnostic implications. Clin Chem. 2011 Dec;57(12): 1650-69.

• Galesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, van Tienoven D, Wetzels JF, Kiemeney LA, Sweep FC, den Heijer M, Swinkels DW. Serum hepcidin: reference ranges and biochemical correlates in the general population. Blood. 2011 Jun 23;117(25):e218-25.

• van Bokhoven MA, van Deursen CT, Swinkels DW. Diagnosis and management of hereditary haemochromatosis. BMJ. 2011 Jan 19;342:c7251 Review.

• Kroot JJ, Laarakkers CM, Geurts-Moespot AJ, Grebenchtchikov N, Pickkers P,van Ede AE, Peters HP, van Dongen-Lases E, Wetzels JF, Sweep FC, Tjalsma H, Swinkels DW. Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders. Clin Chem. 2010 Oct;56(10):1570-9.

• Kartikasari AE, Wagener FA, Yachie A, Wiegerinck ET, Kemna EH, Swinkels DW. Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J Cell Mol Med. 2009 Sep;13(9B):3091-102.